Day 1 San Diego, California, United States

San Diego is a vacationer's paradise, with year-round temperatures in the seventies and near-constant sunshine. One of America's most family-friendly cities, San Diego is home to LEGOLAND, the New Children's Museum, and the famous San Diego Zoo. Sunbathers and surfers are guaranteed to find their perfect beach, and foodies find delights in artisanal breweries, local bistros, and gourmet restaurants. From the Broadway excitement of La Jolla Playhouse to the European feel of Little Italy to the nouveau-chic of the Gaslamp Quarter, San Diego has something for everyone.

Day 5 Klawock, Alaska, United States

Klawock is a city in Prince of Wales–Hyder Census Area, in the U.S. state of Alaska, on the west coast of Prince of Wales Island, on Klawock Inlet, across from Klawock Island. The population was 755 at the 2010 census, down from 854 in 2000.

Day 6 Juneau, Alaska, United States

Juneau, Alaska's capital and third-largest city, is on the North American mainland but can't be reached by road. Bounded by steep mountains and water, the city's geographic isolation and compact size make it much more akin to an island community such as Sitka than to other Alaskan urban centers, such as Fairbanks or Anchorage. Juneau is full of contrasts. Its dramatic hillside location and historic downtown buildings provide a frontier feeling, but the city's cosmopolitan nature comes through in fine museums, noteworthy restaurants, and a literate and outdoorsy populace. The finest of the museums, the Alaska State Museum, is scheduled to reopen in May 2016 on its old site as the expanded Alaska State Library, Archives, and Museum (SLAM) following several years of planning and exhibit research. Another new facility, the Walter Soboleff Center, offers visitors a chance to learn about the indigenous cultures of Southeast Alaska–-Tlingit, Haida, and Tsimshian. Other highlights include the Mt. Roberts Tramway, plenty of densely forested wilderness areas, quiet bays for sea kayaking, and even a famous drive-up glacier, Mendenhall Glacier. For goings-on, pick up the Juneau Empire (www.juneauempire.com), which keeps tabs on state politics, business, sports, and local news.

Day 7 Glacier Bay National Park, Alaska, United States

Located in Southeast Alaska, west of the capital city of Juneau, Glacier Bay is a beautiful National Park full of snow capped mountains, tidewater glaciers and wildlife. Experience wildlife in all its beauty from boat trips for whale watching and hiking through the trails of the Park. It is a protected area full of wonder to be explored.

Day 8 Wrangell, Alaska, United States

A small, unassuming timber and fishing community, Wrangel sits on the northern tip of Wrangel Island, near the mouth of the fast-flowing Stikine River—North America's largest undammed river. The Stikine plays a large role in the life of many Wrangel residents, including those who grew up homesteading on the islands that pepper the area. Trips on the river with local guides are highly recommended as they provide, basically, an insider's guide to the Stikine and a very Alaskan way of life. Like much of Southeast, Wrangel has suffered in recent years from a declining resource-based economy. But locals are working to build tourism in the town. Bearfest, which started in 2010, celebrates Wrangel's proximity to Anan Creek, where you can get a close-up view of both brown and black bears. Wrangel has flown three different national flags in its time. Russia established Redoubt St. Dionysius here in 1834. Five years later Great Britain's Hudson's Bay Company leased the southern Alaska coastline, renaming the settlement Ft. Stikine. It was rechristened Wrangel when the Americans took over in 1867; the name came from Baron Ferdinand Petrovich von Wrangel, governor of the Russian-American Company. The rough-around-the-edges town is off the track of the larger cruise ships, so it does not get the same seasonal traffic that Ketchikan and Juneau do. Hence, it is nearly devoid of the souvenir shops that dominate so many other nearby downtown areas. But the gift shops and art galleries that are here do sell locally created work, and the town is very welcoming to visitors; independent travelers would do well to add a stop in Wrangel during their Southeast wanderings.

Day 9 Ketchikan, Alaska, United States

Ketchikan is famous for its colorful totem poles, rainy skies, steep–as–San Francisco streets, and lush island setting. Some 13,500 people call the town home, and, in the summer, cruise ships crowd the shoreline, floatplanes depart noisily for Misty Fiords National Monument, and salmon-laden commercial fishing boats motor through Tongass Narrows. In the last decade Ketchikan's rowdy, blue-collar heritage of logging and fishing has been softened by the loss of many timber-industry jobs and the dramatic rise of cruise-ship tourism. With some effort, though, visitors can still glimpse the rugged frontier spirit that once permeated this hardscrabble cannery town. Art lovers should make a beeline for Ketchikan: the arts community here is very active. Travelers in search of the perfect piece of Alaska art will find an incredible range of pieces to choose from.The town is at the foot of 3,000-foot Deer Mountain, near the southeastern corner of Revillagigedo (locals shorten it to Revilla) Island. Prior to the arrival of white miners and fishermen in 1885, the Tlingit used the site at the mouth of Ketchikan Creek as a summer fish camp. Gold discoveries just before the turn of the 20th century brought more immigrants, and valuable timber and commercial fishing resources spurred new industries. By the 1930s the town bragged that it was the "salmon-canning capital of the world." You will still find some of Southeast's best salmon fishing around here. Ketchikan is the first bite of Alaska that many travelers taste. Despite its imposing backdrop, hillside homes, and many staircases, the town is relatively easy to walk through. Favorite downtown stops include the Spruce Mill Development shops and Creek Street. A bit farther away you'll find the Totem Heritage Center. Out of town (but included on most bus tours) are two longtime favorites: Totem Bight State Historical Park to the north and Saxman Totem Park to the south.

Day 10 Prince Rupert, British Columbia, Canada

Just 40 mi (66 km) south of the Alaskan border, Prince Rupert is the largest community on British Columbia's north coast. Set on Kaien Island at the mouth of the Skeena River and surrounded by deep green fjords and coastal rain forest, Prince Rupert is rich in the culture of the Tsimshian, people who have been in the area for thousands of years. As the western terminus of Canada's second transcontinental railroad and blessed with a deep natural harbor, Prince Rupert was, at the time of its incorporation in 1910, poised to rival Vancouver as a center for trans-Pacific trade. This didn't happen, partly because the main visionary behind the scheme, Grand Trunk Pacific Railroad president Charles Hays, went down with the Titanic on his way back from a financing trip to England. Prince Rupert turned instead to fishing and forestry. A port of call for both BC and Alaska ferries, but relatively new to cruise ships, this community of 15,000 retains a laid-back, small-town air.

Day 12 Vancouver, British Columbia, Canada

Vancouver is a delicious juxtaposition of urban sophistication and on-your-doorstep wilderness adventure. The mountains and seascape make the city an outdoor playground for hiking, skiing, kayaking, cycling, and sailing—and so much more—while the cuisine and arts scenes are equally diverse, reflecting the makeup of Vancouver's ethnic (predominantly Asian) mosaic. Vancouver is consistently ranked as one of the world's most livable cities, and it's easy for visitors to see why. It's beautiful, it's outdoorsy, and there's a laidback West Coast vibe. On the one hand, there's easy access to a variety of outdoor activities, a fabulous variety of beaches, and amazing parks. At the same time, the city has a multicultural vitality and cosmopolitan flair. The attraction is as much in the range of food choices—the fresh seafood and local produce are some of North America's best—as it is in the museums, shopping, and nightlife.Vancouver's landscaping also adds to the city's walking appeal. In spring, flowerbeds spill over with tulips and daffodils while sea breezes scatter scented cherry blossoms throughout Downtown; in summer office workers take to the beaches, parks, and urban courtyards for picnic lunches and laptop meetings. More than 8 million visitors each year come to Vancouver, Canada's third-largest metropolitan area. Because of its peninsula location, traffic flow is a contentious issue. Thankfully, Vancouver is wonderfully walkable, especially in the downtown core. The North Shore is a scoot across the harbor, and the rapid-transit system to Richmond and the airport means that staying in the more affordable 'burbs doesn't have to be synonymous with sacrificing convenience. The mild climate, exquisite natural scenery, and relaxed outdoor lifestyle keep attracting residents, and the number of visitors is increasing for the same reasons. People often get their first glimpse of Vancouver when catching an Alaskan cruise, and many return at some point to spend more time here.