Day 1 Venice, Italy

Venice is a city unlike any other. No matter how often you've seen it in photos and films, the real thing is more dreamlike than you could imagine. With canals where streets should be, water shimmers everywhere. The fabulous palaces and churches reflect centuries of history in what was a wealthy trading center between Europe and the Orient. Getting lost in the narrow alleyways is a quintessential part of exploring Venice, but at some point you'll almost surely end up in Piazza San Marco, where tourists and locals congregate for a coffee or an aperitif.

Day 3 Messina, Italy

Home to the Museo Regionale of Messina, known for featuring two of Caravaggio's paintings, the city is also famous for having been the capital of the ancient kingdom of Sicily.

Day 4 Naples, Italy

Naples, in the Campania region, is Italy's third largest city. Its claim to fame is the spectacular location along one of the world's most splendid bays, backed by the perfect cone of Mount Vesuvius. In addition to its beautiful setting, Naples' surprises with other outstanding attractions such as the Royal Palace, San Carlos Opera House, the impressive National Archaeological Museum and the Castel Nuovo, dating from the 13th-century. The city's central area is best explored on foot. Chaotic traffic conditions make driving around the city a very frustrating experience. Naples provides a convenient starting point for trips to such favored destinations as Pompeii, Herculaneum and Mount Vesuvius. The Isle of Capri can be reached via a 45-minute hydrofoil service. The region of Campania was home to Greeks settlers some 300 years before Rome was founded. Pompeii, too, was a Greek town before being conquered by the Romans during the 5th century BC. It was under the Romans that Pompeii flourished and grew prosperous. When Mount Vesuvius erupted in 79 AD, the population of 20,000 was wiped out, but dozens of buildings were preserved under layers of cinder more than 20 feet deep. The most important finds from Pompeii are displayed in Naples' National Archaeological Museum. A visit here will no doubt enhance a visit to ancient Pompeii.

Day 5 Civitavecchia, Italy

Italy's vibrant capital lives in the present, but no other city on earth evokes its past so powerfully. For over 2,500 years, emperors, popes, artists, and common citizens have left their mark here. Archaeological remains from ancient Rome, art-stuffed churches, and the treasures of Vatican City vie for your attention, but Rome is also a wonderful place to practice the Italian-perfected il dolce far niente, the sweet art of idleness. Your most memorable experiences may include sitting at a caffè in the Campo de' Fiori or strolling in a beguiling piazza.

Day 7 Barcelona, Spain

The infinite variety of street life, the nooks and crannies of the medieval Barri Gòtic, the ceramic tile and stained glass of Art Nouveau facades, the art and music, the throb of street life, the food (ah, the food!)—one way or another, Barcelona will find a way to get your full attention. The capital of Catalonia is a banquet for the senses, with its beguiling mix of ancient and modern architecture, tempting cafés and markets, and sun-drenched Mediterranean beaches. A stroll along La Rambla and through waterfront Barceloneta, as well as a tour of Gaudí's majestic Sagrada Famíliaand his other unique creations, are part of a visit to Spain's second-largest city. Modern art museums and chic shops call for attention, too. Barcelona's vibe stays lively well into the night, when you can linger over regional wine and cuisine at buzzing tapas bars.

Day 9 Cádiz, Spain

Believed to be the oldest town on the Iberian Peninsula, the Andalusian port of Cádiz enjoys a stunning location at the edge of a six-mile promontory. The town itself, with 3,000 years of history, is characterised by pretty white houses with balconies often adorned with colourful flowers. As you wander around be sure to take a stroll through the sizeable Plaza de Espãna, with its large monument dedicated to the first Spanish constitution, which was signed here in 1812. Cádiz has two pleasant seafront promenades which boast fine views of the Atlantic Ocean, and has a lovely park, the Parque Genoves, located close to the sea with an open-air theatre and attractive palm garden. Also notable is the neo-Classical cathedral, capped by a golden dome.

Day 11 Santa Cruz de Tenerife, Spain

The largest of the Canary Islands, Tenerife is a beautiful and scenic island which enjoys year-round sunshine and is dominated by Mount Teide. The mountain range runs through the centre of the island, with fertile valleys on the northern side. In the central part of the range is the gigantic natural crater of the Cañadas del Teide, about 14 miles in diameter. Santa Cruz, the island's pretty capital, was originally a small fishing village but has now grown into a modern city, and also contains 16th-century civic buildings and ornate private mansions. Near the pier is the Santa Cruz Palmetum, a Botanical Garden covering an area of 29 acres, specialising in palms.

Day 18 Salvador de Bahia, Brazil

According to Salvador's adopted son Jorge Amado, "In Salvador, magic becomes part of the every-day." From the shimmering golden light of sunset over the Baía do Todos os Santos, to the rhythmic beats that race along the streets, Salvador, while no longer Brazil's capital, remains one of its most captivating cities. A large dose of its exoticism comes down to its African heritage—at least 70% of its 2,675,000 population is classified as Afro-Brazilian—and how it has blended into Brazil's different strands, from the native Indians to the Christian colonizers. Salvadorans may tell you that you can visit a different church every day of the year, which is almost true—the city has about 300. Churches whose interiors are covered with gold leaf were financed by the riches of the Portuguese colonial era, when slaves masked their traditional religious beliefs under a thin Catholic veneer. And partly thanks to modern-day acceptance of those beliefs, Salvador has become the fount of Candomblé, a religion based on personal dialogue with the orixás, a family of African deities closely linked to nature and the Catholic saints. The influence of Salvador's African heritage on Brazilian music has also turned the city into one of the musical capitals of Brazil, resulting in a myriad of venues to enjoy live music across the city, along with international acclaim for exponents like Gilberto Gil, Caetano Veloso, and Daniela Mercury. Salvador's economy today is focused on telecommunications and tourism. The still-prevalent African culture draws many tourists—this is the best place in Brazil to hear African music, learn or watch African dance, and see capoeira, a martial art developed by slaves. In the district of Pelourinho, many colorful 18th- and 19th-century houses remain, part of the reason why this is the center of the tourist trade. Salvador sprawls across a peninsula surrounded by the Baía de Todos os Santos on one side and the Atlantic Ocean on the other. The city has about 50 km (31 miles) of coastline. The original city, referred to as the Centro Histórica (Historical Center), is divided into the Cidade Alta (Upper City), also called Pelourinho, and Cidade Baixa (Lower City). The Cidade Baixa is a commercial area—known as Comércio—that runs along the port and is the site of Salvador's indoor market, Mercado Modelo. You can move between the upper and lower cities on foot, via the landmark Elevador Lacerda, behind the market, or on the Plano Inclinado, a funicular lift, which connects Rua Guindaste dos Padres on Comércio with the alley behind Cathedral Basílica. From the Cidade Histórica you can travel north along the bay to the hilltop Igreja de Nosso Senhor do Bonfim. You can also head south to the point, guarded by the Forte Santo Antônio da Barra, where the bay waters meet those of the Atlantic. This area on Salvador's southern tip is home to the trendy neighborhoods of Barra, Ondina, and Rio Vermelho, with many museums, theaters, shops, and restaurants. Beaches along the Atlantic coast and north of Forte Santo Antônio da Barra are among the city's cleanest. Many are illuminated at night and have bars and restaurants that stay open late.