Day 1 Marseille, France

Since being designated a European Capital of Culture for 2013, with an estimated €660 million of funding in the bargain, Marseille has been in the throes of an extraordinary transformation, with no fewer than five major new arts centers, a beautifully refurbished port, revitalized neighborhoods, and a slew of new shops and restaurants. Once the underdog, this time-burnished city is now welcoming an influx of weekend tourists who have colonized entire neighborhoods and transformed them into elegant pieds-à-terre (or should we say, mer). The second-largest city in France, Marseille is one of Europe's most vibrant destinations. Feisty and fond of broad gestures, it is also as complicated and as cosmopolitan now as it was when a band of Phoenician Greeks first sailed into the harbor that is today's Vieux Port in 600 BC. Legend has it that on that same day a local chieftain's daughter, Gyptis, needed to choose a husband, and her wandering eyes settled on the Greeks' handsome commander Protis. Her dowry brought land near the mouth of the Rhône, where the Greeks founded Massalia, the most important Continental shipping port in antiquity. The port flourished for some 500 years as a typical Greek city, enjoying the full flush of classical culture, its gods, its democratic political system, its sports and theater, and its naval prowess. Caesar changed all that, besieging the city in 49 BC and seizing most of its colonies. In 1214 Marseille was seized again, this time by Charles d'Anjou, and was later annexed to France by Henri IV in 1481, but it was not until Louis XIV took the throne that the biggest transformations of the port began; he pulled down the city walls in 1666 and expanded the port to the Rive Neuve (New Riverbank). The city was devastated by plague in 1720, losing more than half its population. By the time of the Revolution, Marseille was on the rebound once again, with industries of soap manufacturing and oil processing flourishing, encouraging a wave of immigration from Provence and Italy. With the opening of the Suez Canal in 1869, Marseille became the greatest boomtown in 19th-century Europe. With a large influx of immigrants from areas as exotic as Tangiers, the city quickly acquired the multicultural population it maintains to this day.

Day 2 Olbia, Italy

Amid the resorts of Sardinia's northeastern coast, Olbia, a town of about 60,000, is a lively little seaport and port of call for mainland ferries at the head of a long, wide bay.San SimplicioOlbia's little Catholic basilica, a short walk behind the main Corso Umberto and past the train station, is worth searching out if you have any spare time in Olbia. The simple granite structure dates from the 11th century, part of the great Pisan church-building program, using pillars and columns recycled from Roman buildings. The basilica has a bare, somewhat somber interior, its three naves separated by a series of arches.

Day 3 Civitavecchia, Italy

Italy's vibrant capital lives in the present, but no other city on earth evokes its past so powerfully. For over 2,500 years, emperors, popes, artists, and common citizens have left their mark here. Archaeological remains from ancient Rome, art-stuffed churches, and the treasures of Vatican City vie for your attention, but Rome is also a wonderful place to practice the Italian-perfected il dolce far niente, the sweet art of idleness. Your most memorable experiences may include sitting at a caffè in the Campo de' Fiori or strolling in a beguiling piazza.

Day 4 Messina, Italy

Home to the Museo Regionale of Messina, known for featuring two of Caravaggio's paintings, the city is also famous for having been the capital of the ancient kingdom of Sicily.

Day 6 Rhodes, Greece

Early travelers described Rhodes as a town of two parts: a castle or high town (Collachium) and a lower city. Today Rhodes town—sometimes referred to as Ródos town—is still a city of two parts: the Old Town, a UNESCO World Heritage site that incorporates the high town and lower city, and the modern metropolis, or New Town, spreading away from the walls that encircle the Old Town. The narrow streets of the Old Town are for the most part closed to cars and are lined with Orthodox and Catholic churches, Turkish houses (some of which follow the ancient orthogonal plan), and medieval public buildings with exterior staircases and facades elegantly constructed of well-cut limestone from Lindos. Careful reconstruction in recent years has enhanced the harmonious effect.

Day 7 Limassol, Cyprus

A major commercial port, cruise ship port of call, and wine-making center on the south coast, Limassol, 75 km (47 miles) from Nicosia, is a bustling, cosmopolitan town, with some of the liveliest nightlife on the island. Luxury hotels, apartments, and guesthouses stretch along 12 km (7 miles) of seafront, with the most luxurious ones just to the north of town. In the center, the elegant, modern shops of Makarios Avenue (where you'll mainly find clothes and shoes) contrast with those of pedestrian-only Agiou Andreou in the old part of town, where local handicrafts such as lace, embroidery, and basketware prevail; make sure you avoid shopping on Wednesday and Saturday afternoons, when many shops close at 2 pm. A luxurious marina that will hold 650 yachts as well as house apartments, shops, and restaurants should further boost the town's lively appeal.

Day 8 Alexandria, Egypt

Founded by Alexander the Great, Alexandria was Egypt's capital for over 1,000 years. Now, it is visited by tourists looking to enjoy some diving and those interested in the Great Library, one of the Seven Wonders of the Ancient World.

Day 11 Sharm El Sheikh, Egypt

The port and town of Sharm-el-Sheikh lies near the southernmost tip of the Sinai Peninsula where the Straits of Tiran meet the Gulf of Aqaba. With its strategic position, the Sinai posed a desirable target for various rulers over the centuries. In recent times, the last battle for the Sinai was fought between Egypt and Israel from 1967 to 1979, ending with a peace treaty signed in Washington, D.C. Since the withdrawal of the Israelis, more and more Egyptians have settled in the Sinai, taking advantage of the booming tourist trade. However, vast interior regions are still sparsely populated. Many Bedouins have been affected by the advent of the 21st century, which is rapidly changing their age-old customs and nomadic lifestyle. As tourism and hotel projects continue to spring up along the Sinai coast, contact with Bedouins not involved in tourism is becoming increasingly rare. Once their nomadic life kept them on the move with their tents; today many Bedouins cultivate grain, vegetables and dates in addition to catering to the tourists. Sharm-el-Sheikh was initially developed by the Israelis during the Sinai occupation. Na'ama Bay, a short drive from the port, has grown from virtually nothing into a sizeable resort since the early 1980s. Between the two towns, a string of hotels line a once-untouched coastline. Resort hotels offer great opportunities for swimming, snorkelling and scuba diving. Glass bottom boat trips are available for those preferring to view the exotic marine life of the Red Sea without getting their feet wet.

Day 12 Safaga, Egypt

Port Safago has been undergoing a transformation, slowly metamorphosing into a holiday rsort. Like other cities on the Red Sea, the commercial port town sits close to great offshore dive sites. Unlike others, however, tourist development hasn't taken off in a meaningful way. But if the mass tourism in Hurghada is a turnoff, Safaga offers a small-scale and much more low-key alternative, though the best dive sites can still be seen on a day trip from Hurghada. Safaga is also the closest beach resort to Luxor and the Valley of the Kings, which lies 200 km (124 mi) to the southwest; when cruise ships offer land excursions to Luxor, they often do so through Safaga.

Day 20 Port Victoria, Seychelles

Day 23 Port Louis, Mauritius

Mauritius' largest city, Port Louis is a vibrant and exciting place whose culture is a mix of African, Chinese and Indian influences. There are activities and sights to keep you busy and explore the different aspects of the city.

Day 24 Possession, Réunion

Day 28 Durban, South Africa

Durban, a glistening jewel on the south-east coast of Africa, is the third largest city in South Africa and the major city of KwaZulu-Natal. It has been a centre of sea trade since before colonisation and now has a flourishing artistic centre, which perfectly complements the vibrant markets and rich cultures of the city. Durban's port is a natural half-moon harbour lined with white sand and azure water, punctuated by the port's many piers which reach into the water like the leaves of a fan. The beaches of Durban's famous Golden Mile stretch along the harbour and are popular all year round, as travellers and locals alike enjoy Durban's warm, humid summers and mild, dry winters.